Recovery of influenza B virus with the H273Y point mutation in the neuraminidase active site from a human patient.
نویسندگان
چکیده
The H275Y oseltamivir resistance mutation confers high-level resistance to oseltamivir in isolates of human A(H1N1) influenza. We report the recovery and identification of an influenza B virus with the H273Y neuraminidase point mutation directly from a human patient. The H273Y influenza B isolate is resistant to oseltamivir and peramivir but sensitive to zanamivir.
منابع مشابه
Recovery of Influenza B Virus with the H 273 Y Point Mutation in the neuraminidase Active 1 site from a Human Patient
Recovery of Influenza B Virus with the H273Y Point Mutation in the neuraminidase Active 1 site from a Human Patient 2 Rachel R. Higgins, * Melissa Beniprashad, 1 Eddie Chong-King, 1 Yan Li, 5 Nathalie Bastien, 3 Donald E. Low 1,2,3 and Jonathan B. Gubbay 1,2, 4 4 1 Public Health Ontario, 81 Resources Road, Toronto M9P 3T1, Canada 5 2 University of Toronto, Ontario, Canada 6 3 Mount Sinai Hospit...
متن کاملIdentification of Neuraminidase Gene Mutations of Influenza A/H3N2 Isolates in Mazandaran Province, 2016-2018
Background and purpose: Influenza is one of the viral infections of the respiratory system, which causes death in high-risk groups every year. The genomic changes of influenza virus make it susceptible to drug resistance, therefore, continuous monitoring of the influenza virus is highly important in order to recognize the efficacy of available drugs. The current study investigated the neuramin...
متن کاملNeuraminidase gene sequence analysis of avian influenza H9N2 viruses isolated from Iran
Influenza A viruses possesses two virion surface glycoproteins including haemagglutinin (HA) and neuraminidase (NA). The NA plays an important role in viral replication and promotes virus release from infected cells and facilitates virus spread throughout the body. To find out any genomic changes that might be occurred on NA gene of avian influenza circulating viruses, we have genetically analy...
متن کاملMolecular Characterization and Phylogenetic Analysis of Neuraminidase Gene in A/H1N1 Influenza Virus Isolates Circulating in Iran, 2014-2015.
Objectives: Influenza is one of the most important emerging and reemerging infectious diseases in the world. The aim of this study is molecular and phylogenetic analyses of the variations in circulating influenza A/H1N1 virus isolates during 2014-2015 in Iran and investigate on the drug resistance conditions in the related Iranian isolates. Material and Methods: Throat samples from Iranian pat...
متن کاملBaculoviral Expression of Influenza A Virus (H1N1 New Caledonia) Neuraminidase in Insect Cells
Background and Aims: Each year, the influenza virus causes moderate to severe infections with a high prevalence throughout the world. Accordingly, an influenza vaccine that ensures protection with only a single dose would be a much more cost effective approach to influenza prophylaxis. Generation of Influenza non-replicating virus-like particles (VLP) in baculoviral expression system is an attr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Journal of clinical microbiology
دوره 50 7 شماره
صفحات -
تاریخ انتشار 2012